5-AMINO-1MQ

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 5-Amino-1-Methylquinolinium (5-Amino-1MQ) is a small molecule compound that acts as a nicotinamide N-methyltransferase (NNMT) inhibitor.

NNMT plays a key role in regulating cellular energy metabolism — and by inhibiting it, 5-Amino-1MQ may increase NAD⁺ levels, enhance mitochondrial efficiency, and support healthy fat metabolism in research environments.

 At the cellular level:

•  Inhibits NNMT enzyme → reduces excessive methylation of nicotinamide
   
•  Preserves NAD⁺ availability → supports sirtuin activation and mitochondrial performance
   
•  Increases metabolic rate → may enhance fat oxidation and energy expenditure
   
•  Improves insulin sensitivity → better glucose utilization in metabolic tissues
   

Metabolic health

Improved glucose regulation and lipid metabolism

Body composition

Reduced fat accumulation, increased energy usage

Cellular function

Elevated NAD⁺ levels, enhanced mitochondrial efficiency

Anti-aging potential

Possible support for longevity-related cellular pathways

Oral capsule or solution

50 – 100 mg daily   

Once daily

Injectable (research format)  10 – 20 mg daily

Once daily or every other day