ARGIRELINE

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Argireline inhibits the SNARE complex formation, which is essential for the release of acetylcholine at neuromuscular junctions.

This leads to a temporary relaxation of facial muscles, reducing the depth and visibility of expression wrinkles.

Key mechanisms observed in research:

1. Reduces neurotransmitter release – limits repetitive facial muscle contractions
    
2. Improves skin elasticity – supports collagen and dermal hydration
    
3. Prevents wrinkle formation – minimizes mechanical stress on skin tissue
    
4. Synergistic with GHK-Cu – enhances rejuvenation and cellular repair
    
5. Supports long-term dermal health – maintains smoother texture and tone
    

Anti-wrinkle

Reduced depth of fine lines and expression wrinkles

Dermal health

Improved elasticity and smoothness

Neuro-cosmetic

Relaxed facial muscle activity

Moisture retention

Enhanced hydration and barrier integrity

Anti-aging research

Reduced mechanical stress on fibroblasts

Topical solution or serum

5–10% Argireline solution

Applied 1–2× daily to target areas

In vitro research

0.01–0.1 mM concentration

Dose-dependent assays

• Onset (observed): 7–15 days of consistent application
   
• Cycle duration (research): Continuous (cosmetic studies)
   
• Synergy: Often combined with GHK-Cu, Matrixyl (Palmitoyl Pentapeptide-4), or Acetyl Octapeptide-3 for enhanced dermal results