DSIP

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DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring neuropeptide first isolated from the brains of rabbits in the 1970s.

It is composed of nine amino acids and is primarily studied for its role in sleep regulation, stress adaptation, and neuroendocrine balance.

Despite its name, DSIP does more than influence sleep — research indicates potential effects on hormone regulation, pain modulation, and overall homeostasis.

DSIP interacts with several neurotransmitter and hormonal systems, helping the body maintain balance under stress and promoting restorative sleep patterns.

Key mechanisms observed in research:

1. Regulates sleep cycles – promotes natural slow-wave (deep) sleep
    
2. Modulates neurotransmitters – influences serotonin, GABA, and melatonin pathways
    
3. Reduces stress hormones – lowers ACTH and cortisol secretion
    
4. Supports recovery & repair – promotes growth hormone (GH) release during sleep
    
5. Neuroprotective effects – stabilizes brain oxidative metabolism and cellular repair
    

Sleep regulation

Promotes deep, restorative sleep patterns

Stress response

Reduces cortisol and normalizes HPA axis function

Hormonal support

Increases GH secretion during sleep cycles

Recovery & repair

Improves tissue recovery and anti-fatigue response

Neuroprotection

Stabilizes oxidative balance and neuronal energy metabolism

Injectable (subcutaneous or intramuscular)

100–300 mcg

1–2 times daily (often before sleep)

Oral / Sublingual (experimental)

300–500 mcg

1 time daily

• Cycle duration (research): 2–4 weeks
   
• Half-life: ~15 minutes (short-acting, rapid onset)
   
• Timing: Typically administered before sleep or during recovery phases
   
• Synergy: Often studied alongside GH-releasing peptides or melatonin modulators