GHK-CU

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 GHK-Cu (Copper Tripeptide-1) is a naturally occurring copper-binding peptide composed of Glycine–Histidine–Lysine complexed with a copper ion.

First identified in human plasma, it is found throughout the body — in saliva, urine, and tissue fluids — and plays a key role in wound healing, tissue remodeling, and cellular regeneration.

GHK-Cu is widely studied for its ability to activate repair genes, stimulate collagen synthesis, and promote youthful skin and hair growth in research environments.

GHK-Cu functions as a signaling peptide that communicates with cells to trigger repair and renewal processes.

Key biological pathways include:

1. Collagen & elastin stimulation – boosts extracellular matrix synthesis
    
2. Anti-inflammatory activity – reduces oxidative and inflammatory stress
    
3. Angiogenesis – supports blood vessel formation and tissue oxygenation
    
4. Neuroprotective effects – promotes nerve regeneration and protection
    
5. Hair growth stimulation – enhances follicular cell proliferation and strength
    

These combined effects have made GHK-Cu one of the most researched cosmetic, regenerative, and anti-aging peptides.

Skin health

Increased collagen, elastin & glycosaminoglycan production

Wound healing

Accelerated tissue repair and reduced inflammation

Hair research

Enhanced follicle growth & reduced miniaturization

Anti-aging

Upregulated regenerative genes & antioxidant enzymes

Cellular protection

Improved DNA repair and stem cell activation

 Topical solution or serum

0.1% – 2% GHK-Cu concentration

Applied 1–2× daily

Injectable (research setting)

2–5 mg per session

2–3× per week

Microneedling research

0.5–1 mg per treatment

Weekly or bi-weekly

• Cycle duration: 4–8 weeks
   
• Half-life: Short (<1 hour free, longer when bound to copper)
   
• Combination studies: Often researched with GHK (non-Cu), GHK-Zn, or BPC-157