Gonadorelin

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Gonadorelin is a synthetic form of Gonadotropin-Releasing Hormone (GnRH) — a decapeptide produced naturally in the hypothalamus.

It functions as the primary hormonal signal that initiates the reproductive cascade, controlling the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the anterior pituitary.

In research, Gonadorelin is studied for its role in reproductive endocrinology, fertility regulation, and pituitary function assessment.

Gonadorelin acts by binding to GnRH receptors on pituitary gonadotroph cells, stimulating the release of LH and FSH in a pulsatile pattern that mirrors natural physiology.

Key mechanisms observed in research:

1. Stimulates pituitary release of LH and FSH
    
2. Activates the hypothalamic–pituitary–gonadal (HPG) axis
    
3. Supports gonadal steroidogenesis — testosterone and estrogen synthesis
    
4. Regulates reproductive cycles and ovulation in experimental models
    
5. Improves hypothalamic-pituitary communication under endocrine stress
    

Reproductive health

Activation of LH and FSH release

Hormonal balance

Regulation of gonadal steroid production

Fertility studies

Induced ovulation and spermatogenesis

Pituitary diagnostics

Used to assess pituitary responsiveness

Endocrine research

Insights into HPG-axis modulation and pulsatility

Injectable (subcutaneous or intravenous)

100–500 mcg

1× daily or per pulse-study design

Pulsatile infusion (experimental)

5–20 mcg per pulse

Every 60–120 minutes

• Half-life: ~2–4 minutes (rapid onset, short duration)
   
• Cycle duration (research): Variable (often short-term, 5–14 days)
   
• Synergistic research: Frequently paired with Kisspeptin or hCG analogues to amplify LH/FSH pathways