KISSPEPTI

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Kisspeptin is a naturally occurring neuropeptide encoded by the KISS1 gene, known as a master regulator of the reproductive hormone axis.

It plays a central role in activating GnRH (Gonadotropin-Releasing Hormone) neurons, which in turn control the secretion of LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone) — two key hormones responsible for fertility, puberty, and hormonal balance.

In research, Kisspeptin is studied for its ability to stimulate the hypothalamic-pituitary-gonadal (HPG) axis, offering potential insights into fertility, hormonal optimization, and reproductive endocrinology.

Kisspeptin binds to the GPR54 (KISS1R) receptor in the hypothalamus, triggering the release of GnRH, which cascades into the release of LH and FSH from the anterior pituitary.

Key mechanisms observed in research:

1. Stimulates GnRH secretion → increases LH & FSH levels
    
2. Regulates puberty onset and reproductive function
    
3. Enhances gonadal steroid production (testosterone & estrogen)
    
4. Influences libido and reproductive behavior
    
5. Supports neuroendocrine signaling and hormonal feedback balance
    

Reproductive health

Activation of HPG axis and gonadotropin release

Fertility studies

Supported ovulation and spermatogenesis in models

Hormonal optimization

Balanced LH/FSH and sex steroid levels

Puberty research

Insights into delayed or precocious puberty mechanisms

Libido & behavior

Modulated sexual motivation and mood pathways

Injectable (subcutaneous or intravenous)

100–200 mcg

1× daily or per study protocol

Alternate models (rodent/in vitro)

0.1–10 μM

Concentration-dependent

• Half-life: ~30 minutes (rapid onset, short systemic action)
   
• Cycle duration (research): Often short-term (5–14 days) in fertility or hormone axis studies
   
• Synergistic research: Sometimes evaluated with GnRH agonists or hCG analogues for enhanced reproductive axis activation