MOTS-c

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MOTS-c (Mitochondrial-Derived Peptide, 16 amino acids) is a mitochondria-encoded peptide that plays a vital role in regulating metabolism, cellular energy, and stress resistance.

It is naturally produced within the mitochondria from the 12S rRNA gene and has become a major focus of research into metabolic optimization, insulin sensitivity, and longevity.

MOTS-c acts as a metabolic regulator by improving how cells respond to stress and utilize energy:

1. Enhances glucose uptake — promotes efficient energy conversion
    
2. Activates AMPK — a key metabolic “master switch” for energy homeostasis
    
3. Improves insulin sensitivity — supports glucose regulation in skeletal muscle
    
4. Increases fat oxidation — shifts metabolism toward fat-burning
    
5. Supports mitochondrial health — improves cell resilience and stress response
    

Together, these mechanisms make MOTS-c an important peptide in metabolic, anti-aging, and exercise performance research.

Metabolic health

Enhanced insulin sensitivity & glucose metabolism

Cellular energy

Improved mitochondrial efficiency

Exercise performance

Increased endurance & fat utilization

Longevity pathways

Activation of AMPK and stress-response genes

Weight management

Reduced fat accumulation in animal studies

5–10 mg - 2–3 times per week