MELANOTAN 2

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Melanotan II (MT-2) is a synthetic analog of the naturally occurring α-Melanocyte-Stimulating Hormone (α-MSH) — a peptide responsible for melanin production, energy regulation, and sexual function.

It was originally developed to study the melanocortin system, which influences skin pigmentation, libido, appetite, and energy metabolism.

In research, MT-2 is studied for its effects on melanogenesis (tanning), metabolic regulation, and sexual arousal pathways.

MT-2 acts as an agonist of melanocortin receptors (MC1R–MC5R), producing a range of biological effects depending on which receptor is activated:

1. MC1R activation – stimulates melanin production in melanocytes, darkening skin pigmentation
    
2. MC3R & MC4R activation – influences sexual arousal, appetite, and energy balance
    
3. MC5R activation – may modulate sebaceous gland activity and immune response
    

Through these mechanisms, MT-2 exhibits effects on skin tone, libido, appetite suppression, and body composition in research contexts.

Melanogenesis

Increased melanin production and UV protection

Sexual function research

Enhanced libido and erectile response

Appetite regulation

Reduced hunger and caloric intake

Energy metabolism

Improved fat utilization and thermogenesis

Photoprotection

Reduced UV-induced DNA damage in skin cells

Injectable (subcutaneous)

250–500 mcg

1× daily during initial phase

Maintenance phase

250 mcg

2–3× weekly

• Loading phase (research): 1–2 weeks
   
• Maintenance phase (research): Continued lower dose thereafter
   
• Half-life: ~30 minutes (rapid onset, short duration)
   
• Synergistic research: Sometimes studied alongside PT-141 (Bremelanotide) for combined sexual and melanocortin pathway effects
   

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