SEMAX

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Semax is a synthetic heptapeptide (seven amino acids) developed from the sequence of ACTH(4-10) — a natural fragment of the adrenocorticotropic hormone (ACTH).

It was originally formulated by Russian neuroscientists as a nootropic and neuroprotective peptide, designed to enhance cognition, memory, focus, and brain resilience under stress.

Unlike stimulants, Semax provides mental clarity and focus without jitteriness or dependency, making it a central subject in cognitive and neuroregenerative research.

Semax works through multiple neuromodulatory and neurotrophic pathways, primarily affecting dopamine, serotonin, and BDNF (Brain-Derived Neurotrophic Factor):

1. Upregulates BDNF & NGF – supports neuron growth and plasticity
    
2. Enhances dopamine & serotonin balance – improves motivation, focus, and mood
    
3. Increases oxygen utilization & neuroprotection – supports cognitive endurance
    
4. Regulates stress hormones – stabilizes the hypothalamic-pituitary-adrenal (HPA) axis
    
5. Improves recovery from fatigue & mental overload – supports adaptive brain performance
    

Cognition

Improved learning, focus, and memory recall

Neuroprotection

Enhanced brain resilience to hypoxia and oxidative stress

Mood regulation

Balanced neurotransmitter activity and mental clarity

Stress reduction

Reduced fatigue and improved emotional stability

Post-injury research

Supported neurological recovery in pre-clinical models

Nasal spray

200–600 mcg per dose

1–2 times daily

Injectable (subcutaneous)

250–500 mcg daily

Once daily

Oral/sublingual (experimental)

500–1000 mcg daily

Once daily

• Cycle duration (research): 2–4 weeks (cognitive or recovery studies)
   
• Half-life: ~10–20 minutes (rapid onset, short systemic duration)
   
• Synergy: Commonly studied in combination with Selank or Cerebrolysin analogues