SERMORELIN

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Sermorelin (GRF 1–29) is a synthetic analog of Growth Hormone-Releasing Hormone (GHRH) — the natural peptide secreted by the hypothalamus that stimulates the pituitary gland to produce and release Human Growth Hormone (HGH).

In research, Sermorelin is studied for its ability to stimulate natural GH production, rather than replacing it exogenously, making it a focus of anti-aging, metabolic, and recovery studies.

 Sermorelin binds to GHRH receptors on pituitary somatotroph cells, initiating a cascade that leads to growth hormone secretion.

It acts upstream of the endocrine axis, promoting natural, pulsatile GH release — a safer and more physiological approach compared to direct GH administration.

Key mechanisms observed in research:

1. Stimulates natural GH and IGF-1 production
    
2. Supports lean muscle growth and fat metabolism
   
3. Improves sleep quality and recovery cycles
   
4. Enhances cellular repair and regeneration
    
5. Supports cognitive and immune function via GH pathways
    

Growth hormone modulation

Stimulated endogenous GH and IGF-1 release

Body composition

Reduced adipose tissue, improved lean mass

Sleep & recovery

Enhanced deep sleep and tissue repair

Cellular health

Improved protein synthesis and regeneration

Anti-aging research

Supported pituitary responsiveness and vitality

Injectable (subcutaneous)

100–500 mcg daily

Once daily (often at night)

Alternate protocol

100–300 mcg

5 nights per week (to mimic physiological cycles)

• Cycle duration (research): 8–12 weeks (sometimes up to 6 months)
   
• Half-life: ~10–12 minutes (short systemic life, prolonged biological effect)
   
• Synergistic research: Frequently studied alongside GHRP-2, GHRP-6, or Ipamorelin for amplified GH response