VIP (Vasoactive Intestinal Peptide)

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Vasoactive Intestinal Peptide (VIP) is a naturally occurring neuropeptide composed of 28 amino acids, first isolated from the small intestine.

It functions as both a neurotransmitter and hormone, exerting wide-ranging effects on the cardiovascular, respiratory, immune, and digestive systems.

In research, VIP is studied for its vasodilatory, anti-inflammatory, and neuroprotective properties, as well as its ability to modulate immune function and promote cellular repair.

VIP interacts with VPAC1 and VPAC2 receptors, triggering adenylate cyclase activation and raising intracellular cAMP, which leads to smooth-muscle relaxation, immune modulation, and neuroprotection.

Key mechanisms observed in research:

1. Vasodilation – relaxes blood vessels and improves oxygen delivery
    
2. Neuroprotection – protects neurons from oxidative and inflammatory stress
    
3. Anti-inflammatory regulation – suppresses TNF-α, IL-6, and pro-inflammatory cytokines
    
4. Immune modulation – shifts immune balance toward anti-inflammatory Th2 responses
    
5. Tissue repair – enhances epithelial regeneration and mucosal protection
    

 Vascular health

Improved circulation and oxygenation

Neurological function

Protection against neuroinflammation and stress

Respiratory research

Supported bronchodilation and airway balance

Digestive support

Enhanced intestinal motility and mucosal integrity

Immune balance

Modulated cytokine profile and inflammatory response

Injectable (intravenous/subcutaneous)

50–100 mcg

1–2× daily

Inhaled (aerosolized, experimental)

5–50 mcg per inhalation

1–3× daily

In vitro studies

1–10 μM

Concentration dependent

• Cycle duration (research): 1–4 weeks
   
• Half-life: ~1–2 minutes (rapid degradation; short systemic duration)
   
• Synergistic research: Sometimes studied alongside Thymosin Alpha-1 or BPC-157 for immune and inflammatory modulation